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Maintenance treatments are usually less frequent and less intense than the initial course of injections but can be necessary to sustain the desired effects

Moreover, AS-IV enhances the chemosensitivity of colorectal cancer cells to cisplatin, with part of its mechanism involving the suppression of NOTCH3 expression (Xie et al., 2016)

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As a result, clinicians have avoided using GLP-1 receptor agonists in patients with a history of acute pancreatitis